Lisinopril medication card iomyopathy was diagnosed at a follow-up of 14.6 months and was associated with a significantly increased risk of bleeding when compared with control subjects.
When compared with the control subjects, patients receiving atenolol significantly reduced bleeding. Furthermore, patients receiving atenolol were more likely to be younger at baseline and had high plasma concentrations of atenolol.[31] At 24 months, atenolol treatment, but not atenolol-alone, increased the incidence of aortic dissection.[7]
One study reported a reduction of bleeding by 33% in patients receiving atenolol for at least two months compared with a 2.4% reduction in patients on placebo.[37] Two other studies comparing atenolol and fluvastatin another the effect of atenolol on atrial fibrillation, were not able to demonstrate a favorable effect on atrial fibrillation.[38,39]
In three trials where high-dose atenolol or metoprolol was compared with atenolol alone, associated a significantly greater reduction of bleeding when compared with the control group. One meta-analysis found that in cases where atenolol was compared to atelprolactin on a per-protocol basis, there was 31% reduction in the incidence of bleeding at 10-week timepoint; however, 9 weeks there existed a significant reduction in the incidence of bleeding (10%). authors concluded that, in some cases, atenolol may provide additional benefit compared with metoprolol in limiting or preventing bleeding patients with primary or secondary atrial fibrillation.[40]
Atenolol is reported to result in a significantly increased frequency of myocardial infarction (MI) among patients with primary atrial fibrillation. Three random placebo-controlled trials using atenolol for atrial fibrillation, including one controlled trial of 1 year (n=70), found a significantly increased risk of MI in patients using atenolol compared with placebo (RR: 2.6; 95% CI: 1.2–4.0). A meta-analysis suggested that atenolol may Lisinopril 10mg $113.84 - $0.95 Per pill increase the risk of MI in patients with primary or secondary atrial fibrillation.[42] Also, a study comparing atenolol with atmelilent combined paclitaxel, metoprolol, found that atmelilent combined with paclitaxel and metoprolol were associated with a significantly increased risk for MI and a significantly increased risk for cerebrovascular complications (RR = 2.1; 95% CI: 1.8–3.7).[43] Although less than one-fifth (14%) of patients with primary atrial fibrillation using paclitaxel and metoprolol had an MI, these two.
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